Let's Talk About Supplementation #13

Are we close to the perfect combination?

Research has long since developed positive allosteric modulators (PAMs) of the α7 nicotinic acetylcholine receptors. These molecules have shown exceptional results in a wide range of neurodegenerative diseases, and even in conditions related to the autism spectrum or attention deficit disorders.

These molecules have been developed through bio-computing engineering and tested in vivo. They are synthetic and possess an unparalleled therapeutic action. However, for unknown reasons, most of them remain not marketed by major laboratories. Are they dangerous? Too expensive? Or are they simply too effective and thus threaten more profitable pharmaceuticals? All speculations remain possible.

Regardless, our issue concerning FQAD is not even there, since even if these molecules were commercialized, it would still take several years before health authorities could include FQAD within the therapeutic framework of these compounds.

This therefore concretely means that for most patients today, they have no other choice but to turn toward naturally occurring molecules of lower potency—available in the form of supplements, foods, or herbal teas—and to adapt their diet accordingly.

I therefore believe that implementing a strategy targeting multiple metabolic pathways simultaneously may prove highly effective, especially when combined with a strict dietary regimen to control blood sugar and with avoidance of certain foods such as chocolate or caffeine, alcohol. I also think about the benefits of sunlight and oxygen, which can simultaneously stimulate multiple metabolic pathways usually impaired in FQAD.

Identifying genetic weaknesses may also alleviate the “double hit,” by relieving the second hit. For example, a person with elevated homocysteine levels must do their best to improve methylation and investigate which vitamins and minerals they should take in order to optimize their markers.

Generally speaking, every individual who has developed FQAD should strive to optimize their nutritional, thyroid, intestinal, and immune status.

Finally, there remains the aspect specific to fluoroquinolone toxicity.